Pancreatin: instructions for use

Pancreatin: instructions for use

Pancreatin is a digestive enzyme preparation that consists of three components:

  • amylase,
  • lipase,
  • protease.

They are natural enzymes of the pancreas and when using Pancreatin they complement the functioning of this organ, or else they completely replace its activity. In most cases, it is used to compensate for the insufficiency of the pancreatic secretory function.

Pancreatic enzymes in Pancreatin are as follows:

  • proteins in the gastrointestinal tract are broken down into amino acids;
  • fats are broken down into glycerin and fatty acids;
  • Starch is broken down into dextrins and monosaccharides.

In addition to improving etching processes, the use of Pancreatin has a positive effect on the overall functional state of the gastrointestinal tract, compensates for the lack of enzymes in the pancreas, and also has a proteolytic, aminolytic and lipolytic effect.

For the production of the drug is used the pancreas of animals (most often pigs and cattle). Available Pancreatin in the form of tablets or pills, each of which contains 8000 units in terms of lipase.

Indications for use

Pancreatin is prescribed for the following diagnoses:

  • functional disorders of the digestive system caused by problems with chewing, or with prolonged immobility of the patient;
  • late pancreatitis, which is often the result of a transplant;
  • chronic forms of liver and biliary tract diseases;
  • digestive problems associated with unusual or heavy food for the body;
  • insufficiency of the digestive tract;
  • cystic fibrosis of the pancreas;
  • inflammatory processes in the organs of the gastrointestinal tract.

This is far from an exhaustive list of indications for the use of Pancreatin, but it affects most of the pathologies in whose therapy this drug is used. In addition to diseases, Pancreatin is also used as a preparation for an ultrasound or x-ray examination of the abdominal organs.

Dosage and administration

Doses of Pancreatin are selected in accordance with the individual characteristics of the patient and, in most cases, are calculated depending on the degree of development of pancreatic insufficiency. Averaged instructions for use of Pancreatin says that it is prescribed up to four tablets with each meal, which approximately is about 16,000 IU of lipase per day. This is considered the maximum daily dose for an adult patient.

At the same time, absolute renal insufficiency is a prerequisite for increasing the maximum dosage of Pancreatin, and it can be administered in the amount of 50 tablets per day. It is not the quantity itself that should frighten here, but the diagnosis at which it was appointed. In fifty tablets of the drug contains the daily need of the human body in lipase.

For children, Pancreatin is tentatively assigned as follows:

Age Dose
Children two to four years old One tablet per seven kilograms of weight
Kids over four years old One tablet per 14 kilograms of weight

At the same time and here the numbers are just a guideline and are not instructions for use. Appointment and dosage of Pancreatin are carried out exclusively by a doctor, taking into account all the features of the patient and the pathology.


Pancreatin cannot be used for the following diseases:

  • acute and chronic pancreatitis,
  • liver failure, precoma or coma,
  • obstructive jaundice,
  • intestinal obstruction,
  • cholelithiasis,
  • hepatitis,
  • hyperbilirubinemia.

In addition, Pancreatin is not assigned to children under two years of age, and during periods of pregnancy and lactation its use is not recommended. In this case, it is necessary to compare the expected effect of the use of Pancreatin and the likely harm to the pregnant woman and fetus.

Another contraindication to the use of Pancreatin is individual intolerance to its components.


When overdosing with Pancreatin, the following problems may occur:

  • increase in blood uric acid
  • diarrhea ,
  • nausea,
  • change in stool character,
  • constipation,
  • epigastric pain.

Release form

The drug is available in two forms:

Release form Packaged Quantity
Gastro-resistant tablets 10, 20, 50, 60 pieces
Dragee 50 pieces


Pancreatin analogs may be the following drugs:

Drug Description
Kreazim The preparation of the enzyme group of animal origin. It has a stimulating effect on the digestive processes. The indications for its use almost completely repeat the indications for the use of Pancreatin.
Creon The drug is based on porcine pancreatin. Gelatin structure contributes to the speed of Creon in the stomach. Not absorbed into the blood. Pharmacological effects are almost completely in the intestinal lumen.
Mezim An enzyme preparation with a pronounced pancreatic protective effect. Improves the process of splitting and absorption of proteins, fats and carbohydrates, and other nutrients.
Pangrol Pangrol contains lipase, amylase, and prosthesis, which provide the drug with lipolytic, proteolytic and aminolytic effects.
Panzinorm A drug whose components can replace enzymes secreted by the stomach and pancreas. In addition, Panzinorm activates the secretion of these organs.
Pancreatic A complete analogue of Pancreatin with identical composition and pharmacokinetics.
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