Omez is a drug widely represented in pharmacies of Eastern Europe. Therapy of diseases of the stomach and intestines includes a variety of drugs, and the use of Omez in the treatment tactics, despite the indications for receiving a peptic ulcer, is not limited only to this pathology. The instructions for use of the medication describe in detail when Omez may be included in the complex therapy of diseases of the gastrointestinal tract, how to take the drug, what therapeutic and side effects are likely if the prescribed doses are observed and not followed.
What kind of drug is Omez?
Omez refers to the means of directional action from the group of anti-ulcer drugs related to proton pump inhibitors. The active substance and its main analogue is omeprazole, a chemical compound that blocks the synthesis of hydrochloric acid in the last stage.
Hydrochloric acid is an indispensable element of the digestive process, ensuring the separation of food into its constituent elements and facilitating its absorption in the small intestine. An excess of this acid irritates the walls of the stomach, which is especially negative in the presence of erosions and ulceration of the mucous membrane. Suppression of the secretion of hydrochloric acid by taking Omez reduces irritation of the stomach walls, regardless of etiology and type of stimulus.
Domperidone is the second component of Omez D, a combined drug based on omeprazole. This substance has an additional effect on the smooth muscles of the digestive tract. Due to the presence of domperidone, Omez D has an antiemetic effect, reduces the likelihood of reflux, manifestations of heartburn, leading to a state of increased tone the muscle tissue of the lower esophageal sphincter, and also causes intestinal contractions, which increases its motility and accelerates the emptying process.
Omez and Omed D are almost immediate-acting drugs. The therapeutic effect occurs within 45-60 minutes after oral administration and lasts for 24 hours. The maximum concentration of active substances is noted 2 hours after administration. The decrease in the concentration of hydrochloric acid with a daily intake reaches a figure of 70-80%, depending on the individual reactions of the patient. To achieve a single therapeutic effect, a course of administration of at least 4 days is recommended.
The active substances of the drugs are absorbed in the gastrointestinal tract, the metabolization process takes place in the liver tissues, output in the form of a metabolite is carried out by the kidneys with urine (80%) and intestines with feces (20%). The blocking of the secretory function of the stomach disappears after the cancellation of the course of treatment on its own within 3 days, the level of synthesis and secretion is restored.
Various forms and composition
Omez is a drug that is presented in several versions, both in the form of the drug release and in its composition. Monocomponent Omez is available in two forms:
- Enteric-coated capsules. The composition includes 20 mg of the active substance (omeprazole) and related components. The capsules are made on the basis of gelatin, consist of transparent and pink transparent parts, each of which has the inscription OMEZ. Inside the enteric capsule are rounded white granules. Capsules are packed in plastic strips, covered with foil. Omez carton packs contain 3 strips of 10 capsules each;
- Omez Insta is an Omez drug release form intended for patients who have difficulty in swallowing capsules. As part of the drug omeprazole (20 mg per dose), related substances: sucrose, xylitol, mint flavored flavoring, sodium bicarbonate, gum. The drug is available in powder form for the independent preparation of a suspension (a mixture of the drug in a liquid). Each dose of the drug is placed in a separate paper bag with protection from moisture, depending on the number of bags in the package, Omez Insta No. 5, No. 10, 20, 30 is emitted.
Omez D – a drug of combined action, based on the presence in the composition of omeprazole and domperidone (10 mg, respectively). Available in the form of enteric gelatin capsules, consisting of two parts: purple and transparent, with the name of the drug and the logo to protect against fakes. In the capsule, the active substances are presented in the form of a white powder. This form is represented by number 10, in each carton package – 10 capsules of the drug.
In hospitals and clinics, the drug can be presented as a dry mix, intended for infusion transfusions, mainly for the prevention of postoperative complications.
Indications for taking Omez
Omez – a drug with a fairly wide range of indications, despite belonging to the group of anti-ulcer drugs. His appointment is justified in the following cases:
- in the course of treatment and during preventive measures of exacerbations, chronic course, relapses of gastric ulcer and duodenal ulcer;
- if you have symptoms of reflux esophagitis;
- in identifying hypersecretion of the stomach (stressful lesions of the stomach walls caused by increased synthesis of hydrochloric acid, Zollingen-Ellison syndrome, systemic manifestations of macidosis, adenomatosis of polyendocrine etiology, etc.);
- ulcerative, erosive lesions of the walls of the gastrointestinal tract with long-term use of non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, etc.);
- as part of a combination therapy as a proton pump inhibitor for pathologies and diseases of the gastrointestinal tract caused by microorganisms H. pilori.
Omez D is used for manifestations of dyspepsia, gastroesophageal reflux resistant to other drugs, gastritis accompanied by increased acidity of the gastric environment, hypersecretion of the stomach, etc.
Contraindications to receiving Omez and Omez D
The prescription of Omez and Omez D drugs, in accordance with the instructions for use, is limited in the following cases:
- early childhood. The use of Omez in children is strictly limited to specific indications and age limits;
- presence of individual intolerance to the components of the drug (fructose, sucrose, benzimidazoles, etc.), hypersensitivity reactions;
- with mechanical obstruction of the intestine, perforation of the walls, the presence of bleeding in the organs of the gastrointestinal tract, prior treatment of surgery in the gastrointestinal
- when combined with several medications, including warfarin, diazepam, ketoconazole, clarithromycin, preparations of Hypericum perforatum (decoctions, tinctures, encapsulated and tableted products based on a medicinal plant), etc.
For kidney, liver failure, history of jaundice, episodes of ulcer perforation, as well as during pregnancy and lactation, omeprazole preparations are taken only according to the testimony of a doctor.
Omez Admission Rules
The duration of the course of therapy and the required dosage are set by the attending physician based on the diagnosis, clinical picture of the disease (duration of the disease, stage, severity of symptoms), the presence of comorbidities and the patient’s individual characteristics.
According to the instructions, the drug in any of the above forms taken orally. The recommended time of admission is half an hour before meals or during meals. Capsules are swallowed whole, without chewing, washed down with a sufficient amount of liquid. If necessary, you can take granules without the capsule shell, mixing them with water with a small amount of acid (lemon, citrus juice). It is forbidden to mix granules with milk or dairy products, carbonated drinks. The resulting mixture is consumed immediately, can not be stored.
If it is impossible to take the capsules entirely, experts recommend not using the granule dissolving method, but using the Omez Inta suspension form. To mix the suspension, pour the contents of the bag into a clean container and add up to 2 tablespoons of boiled water at room temperature.
Depending on the disease and the course of treatment, it is possible to receive from 1 to 6 capsules or Omez powders per day, the duration of therapy depends on the goals. In preparation for surgery, a single dose is possible, in the treatment of diseases of the gastrointestinal tract, the average treatment duration is 2-8 weeks.
Likely side effects
The drug is fairly well tolerated by patients with a low likelihood of side effects. In studies of monocomponent Omez, the following possible side effects have been identified:
- blood shift due to hematopoietic disorders (thrombocytopenia, agranulocytosis, pancytopenia, leukopenia);
- in the presence of diseases and pathologies of the central nervous system while receiving Omez, headaches, irritability, dizziness, depressive states can be observed;
- on the part of the organs of the gastrointestinal tract, such side effects of the drug as nausea, dyspepsia, vomiting, dry mouth, induration, discoloration of feces (melena), etc. may occur;
- allergic skin reactions, hypersensitivity to UV rays, hair loss can occur.
If you experience this symptom, you should consult with your doctor.
Omez: analogues and substitutes
The analogues of this drug include all monocomponent agents based on omeprazole, as well as pantoprazole (medication Nolpaz). Among them may be drugs with different dosages, the country and the company manufacturer. Direct counterparts include: Omeprazole, Gastrozole, Omezol and others.
What is the difference between this drug and its analogues? Omeprazole, a drug with the same active ingredient, unlike Omez, was produced not in India, but in Russia. The amount and chemical formula of the active substance are the same, but there are no additives in Omeprazole, which, on the one hand, reduces the likelihood of allergic reactions and individual intolerance to additional substances, on the other hand, it increases the likelihood of side effects. The form of release is the same – capsules with an enteric coating of the shell.