Mexidol: instructions for use and analogues

Mexidol: instructions for use and analogues

Mexidol is a drug made from ethyl methyl hydroxypyridine succinate. This substance is a membrane protector – a drug to protect the body cells from various kinds of effects, including the destruction of free radicals. In addition to this function, Mexidol also has the following effects:

  • antihypoxic – increasing resistance to hypoxia and improving oxygen utilization that circulates in the body;
  • Protective stress – protection of life support systems from the negative impact of an emotional nature;
  • nootropic – a specific effect on the higher mental functionality of the brain;
  • antiepileptic – suppression of muscle cramps of various genesis;
  • anxiolytic – reducing anxiety, anxiety and fear.

Pharmacological action

The main directions of the drug on the human body due to the effectiveness of its active ingredient – ethylmethylhydroxypyridine succinate. Mexidol demonstrates effectiveness in normalizing the oxygen supply of tissues and the processes of its assimilation, improving memory processes, reducing the harm from ingestion of toxins (often alcohol) in the body, increasing resistance to problems associated with oxygen-dependent pathologies.

In addition, the positive effect of Mexidol on changes in atherosclerotic vessels, problems with cerebral hemodynamics and platelet sticking has been proven.

Mexidol Release Forms

The drug is available in three forms:

  • Mexidol 125mg # 10 coated tablets. Packaged in a contour cellular blister of ten;
  • injection for intravenous or intramuscular injection of 50 mg / ml No. 5. Packaging – five ampoules in contour cells;
  • MEXIDOL toothpaste in several varieties.

Mexidol Indications

Mexidol is prescribed for the following groups of pathologies:

  • circulatory disorders of the brain with an acute pattern of leakage;
  • dyscirculatory encephalopathy – a vascular lesion of the brain, characterized by a slow course, of a multifocal or diffuse type;
  • vascular dystonia;
  • atherosclerosis;
  • abstinence syndrome (popularly known as “breaking” and occurring after an abrupt cessation of drug or alcohol use);
  • other diseases associated with tissue hypoxia;
  • oral problems: gingivitis, stomatitis, periodontitis, caries.

Mexidol Instructions for Use

The dosage of the drug and the choice of the form of release of Mexidol depends on the disease in the therapy of which it is applied. As a table, we consider the approximate tactics of using Mexidol in the main pathologies, since the final doses and duration of treatment are determined solely by the doctor, based on the nature of the disease, the condition and the individual characteristics of the patient.

Pathology Used Form Mexidol Daily Dosage Duration of treatment
Mild traumatic brain injuries and their consequences Tablets Not more than 800 mg per day, divided into three doses. Can range from five days to two months.
Cerebrovascular accident Solution for injection Up to 300 mg of Mexidol in the first four days by means of a dropper, then intramuscular injections three times a day with 100 mg of the drug. Up to two weeks.
Abstinence syndrome Tablets Two tablets twice a day. In severe pathology, the same single dose can be administered three times a day. Five to seven days.
Atherosclerosis Solution for injection Up to 300 mg per day, divided into several intramuscular injections. Up to six weeks.
Dyscirculatory encephalopathy Solution for injection Up to 500 mg Mexidol intravenously twice a day. 14 days.
Neuroleptic intoxication Solution for injection Up to 500 mg per day. Seven to 14 days.
Necrotic pancreatitis Solution for injection 200-800 mg per day, depending on the severity of the pathology. Until a visible therapeutic effect, after the manifestation of which, the dose of the drug is gradually reduced to zero.
Gingivitis, stomatitis, periodontitis, caries Toothpaste Twice a day. Constantly for therapy and as a prophylactic.

For the dropper, injectable water is used as a solvent for Mexidol. The rate of drip is 60 drops / m, the duration of the jet – up to seven minutes. In most cases, the use of Mexidol, its reception ends with a slow decrease in dose until complete cessation of use.

Probable side effects from taking Mexidol

It is believed that this drug is quite well accepted by the body of almost all categories of patients. Rarely, Mexidol therapy may be accompanied by the following adverse effects:

  • dry mouth,
  • nausea,
  • allergic reactions.

In general, Mexidol is a drug with extremely low toxicity that does not affect motor and coordination activity. Even taking large doses of Mexidol does not manifest additional side effects.


Mexidol is not prescribed in the following cases:

  • age to 12 years;
  • period of pregnancy and lactation;
  • acute renal failure;
  • acute liver failure;
  • individual intolerance to the components of the drug.

In addition, patients with arterial hypertension, accompanied by crises, and low blood pressure require special attention when taking Mexidol.

Mexidol Analogs

Ethylmethylhydroxypyridine succinate, in addition to the name Mexidol, is found in pharmacies under a variety of commercial names: Mexico, Mefifil, Meksidant. In terms of its chemical structure, this entire series is absolutely identical drugs, which, in addition to the composition, are the same in both the dosage forms and dosages. The only difference is the pathologies in which each of them is predominantly assigned. But there is no substantiated confirmation of such a distribution.

As for other drugs with similar pharmacological action, here in pharmacies are most often found:

Drug Description
Neurox The drug is for intravenous and intramuscular injections. The active ingredient is ethylmethylhydroxypyridine succinate. Neurox’s action is similar to that of Mexidol.
Cerecard An antioxidant drug based on ethyl methyl hydroxypyridine succinate. The mechanism of action is similar to Mexidol.
Hypoxen The active substance of Hypoxen is sodium polyhydroxyphenylene thiosulfonate. The drug has on the body antihypoxic, antioxidant, metabolic, hypotensive and vasodilating effects. Effective to stimulate tissue respiration during hypoxia.
Riluzole A drug used in amyotrophic lateral sclerosis. Allows to carry out therapy without the use of artificial ventilation of the lungs and tracheostomy. The action of Riluzole is to block the sodium channels, which in the active state provoke the death of neurons.
Vitagamma A medicine designed to replenish the necessary vitamin balance in the body. It is prescribed for neurological pathologies provoked by vitamin deficiency, and also as an element of complex therapy for neuritis, polyneuritis, neuralgia, polyneuropathy.
Emoxibel A drug for the treatment of acute and chronic circulatory disorders of the brain of an ischemic or hemorrhagic nature. Emoxibel’s action is aimed at reducing the permeability of blood vessels and capillaries, reducing blood viscosity, expanding coronary vessels.
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